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SOCKET, Woolfson Group, University of Bristol
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The CC+ Database, a detailed, searchable repository of coiled-coil assignments, which is freely available at http://coiledcoils.chm.bris.ac.uk/ccplus. Coiled coils were identified using the program SOCKET, which locates coiled coils based on knobs-into-holes packing of side chains between α-helices. There are two points of entry into the CC+ Database: the "Periodic Table of Coiled-coil Structures", which presents a graphical path through coiled-coil space based on manually validated data, and the "Dynamic Interface", which allows queries of the database at different levels of complexity and detail. The latter entry level, which is the focus of this article, enables the efficient and rapid compilation of subsets of coiled-coil structures. These can be created and interrogated with increasingly sophisticated pull-down, keyword and sequence-based searches to return detailed structural and sequence information. Also provided are means for outputting the retrieved coiled-coil data in various formats, including PyMOL and RasMol scripts, and Position-Specific Scoring Matrices.
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The SPIRICOIL database, a unique resource for the study of the protein super-secondary structure coiled coils is freely available at http://supfam.cs.bris.ac.uk/SUPERFAMILY/spiricoil/. It provides coiled coil annotations of all currently sequenced genomes as well sequence databases such as Uniprot. It also contains structural and evolutionary information of each of the known coiled structures. It is also possible to enter your own sequences in order to see if they are predicited as being coiled coil containing or not. This website accompanies the currently submitted work by Rackham et al, 2009. If you have any further questions or would like to use this resource in a manor that is not possible through the website please contact us.
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Socket